Globin gene gains credentials

Chicken globin gene number.

Using complementary DNA prepared from adult chicken globin messenger RNA, we show the existence of 2-3 non-cross-hybridising globin sequences in the chicken genome, each of which is present in only one copy per haploid genome. This was done by solution hybridization to total DNA under conditions of cDNA excess. The data agreses with results of RNA-driven hybridisation of globin complementary DN...

-globin gene families

Gabriela Aguileta *, Joseph P. Bielawski 3,4 and Ziheng Yang 1 1 Department of Biology, University College London, Darwin Building, Gower Street, London WC1E 6BT, England 2 Linnaeus Centre for Bioinformatics, University of Uppsala, BMC, Box 598, 75124, Uppsala, Sweden 3 Department of Biology, Dalhousie University, Halifax, Nova Scotia, B3H 4J1, Canada 4 Department of Mathematics & Statistics, D...

TMEM8 – a non-globin gene entrapped in the globin web

For more than 30 years it was believed that globin gene domains included only genes encoding globin chains. Here we show that in chickens, the domain of alpha-globin genes also harbor the non-globin gene TMEM8. It was relocated to the vicinity of the alpha-globin cluster due to inversion of an approximately 170-kb genomic fragment. Although in humans TMEM8 is preferentially expressed in resting...

Globin gene switching in transgenic mice carrying HS2-globin gene constructs.

We have examined the pattern of human globin gene switching in transgenic mice containing three different gamma and beta gene constructs (HS2G gamma A gamma delta beta, HS2A gamma beta neo, and HS2A gamma en beta) and compared the results with previously described transgenics (HS2A gamma beta, HS2G gamma A gamma-117 delta beta, and LCR epsilon G gamma A gamma delta beta). Developmental regulati...

β-Globin Gene Regulation and Nuclear Organisation